What is Glaucoma?

Glaucoma is an eye disease where the optic nerve located at the back of the eye becomes damaged. In most cases this is caused by high pressure inside the eye (intraocular pressure), however in some cases there is a normal intraocular pressure and other factors are involved. Without treatment, the loss of vision usually gets worse over the course of many months or several years.


The loss of vision in glaucoma is permanent, but with early treatment, the damage to vision can be minimised. Most patients with glaucoma are not aware of problems with their vision. This is because the central vision (for reading and recognising people) is only affected when glaucoma has advanced to a late stage. Even when central vision is still good, glaucoma may affect the vision needed for driving and getting about (for instance, seeing steps). Blindness from glaucoma is rare. If blindness does occur, it is usually because the glaucoma is already advanced when it is first diagnosed, because the eye pressure has not responded well to treatment or because patients have not taken their drops regularly. For most glaucoma patients, the main effect of the condition is the inconvenience of taking eye drops.


How common is it?

Glaucoma of some type is found in about 2 per cent of the population over the age of 40. It can also affect children and young adults, although much less frequently. It is estimated that more than 500,000 people suffer from glaucoma in England and Wales alone, with more than 70 million people affected across the world. The great majority of those with glaucoma have a chronic (slowly developing) form of the condition, primary open angle glaucoma (POAG), and studies have demonstrated that half of all cases remain undiagnosed.


Is it inherited?

Close blood relatives of patients with POAG have at least a four-fold increased risk of glaucoma compared with those without a family history of glaucoma. People from families in which a member has glaucoma should be tested for glaucoma from the age of 40 onwards. People with other glaucoma risk factors in addition to the family history (e.g. being of African-Caribbean origin or having diabetes) should be tested from an even earlier age.

How is glaucoma diagnosed?

As stated, persons over 40 years of age with a family history of glaucoma should have regular examinations with an optician, which are free on the NHS. All individuals over 60 years of age are eligible for free NHS eye tests. No single test accurately detects glaucoma and your optician should perform the three glaucoma tests as follows:


1) Tonometry - This is the measurement of eye pressure. Opticians commonly do this by the 'air-puff' technique.


2) Visual field test (perimetry) - this is the formal mapping of the field of vision by a computerised technique. This can identify damage caused by glaucoma and in fact can detect very early changes.


3) Optic disc examination - The nerve tissue at the back of the eye should be examined with a special instrument to look for signs of damage.


Can glaucoma be treated?

The treatment of glaucoma has developed considerably over recent years and new, more potent drugs with fewer side effects than earlier medications are now available. Surgical techniques have also improved and it is estimated that around 95 per cent of those diagnosed early with glaucoma in the UK will retain useful sight for life.


Treatment of Glaucoma

The loss of vision in glaucoma is permanent, but with early treatment, the damage to vision can be minimised. In some patients, the loss of vision occurs very slowly and treatment may not be necessary. However, most patients do require treatment. This prevents or slows further loss of vision in most patients. Taking the treatment is important, even though the vision may seem normal, because the loss of vision may get worse without the patient noticing.


All treatment for glaucoma is designed to reduce the level of intraocular pressure to a point at which further damage to the optic nerve is prevented. This reduction in the level of intraocular pressure is achieved by a variety of means including eye drops, tablets, laser treatments for glaucoma and surgery for glaucoma. Each has advantages and disadvantages and the choice of the glaucoma management regime best suited to an individual patient should be made as a collaborative decision involving the patient and the ophthalmologist.


Eye drops usually form the first stage of treatment for glaucoma. There are now a wide variety of eye drops which work in a number of different ways. Most commonly the drops act to reduce the amount of aqueous humour being produced by the ciliary body, some increase the outflow of aqueous humour from the eye either by the conventional outflow pathway through the trabecular meshwork, or by the non-conventional outflow pathway (also known as the uveoscleral outflow pathway), and some do some of each.


The only tablet commonly used in the treatment of glaucoma is Acetazolamide (Diamox), which is a very powerful type of water tablet. It is most commonly used in the short term treatment of acute angle closure glaucoma prior to laser iridotomy and is rarely prescribed for long term use due to its side effect profile.


Lasers are used to treat both open and closed angle glaucomas with different lasers and different techniques used according to need.


There are also a variety of types of surgery for glaucoma depending on the individual needs of the patient.


Treatment for glaucoma is effective and in the vast majority of cases useful sight can be retained for life providing the treatments are used properly and the agreed management regime followed.




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This website exists to provide further information about ocular conditions to patients, and their families, optometrists and GPs.

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